- 行业: Government
- Number of terms: 22108
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A method for amplifying a DNA base sequence using a heat-stable polymerase and two 20-base primers, one complementary to the (+) strand at one end of the sequence to be amplified and one complementary to the (-) strand at the other end. Because the newly synthesized DNA strands can subsequently serve as additional templates for the same primer sequences, successive rounds of primer annealing, strand elongation, and dissociation produce rapid and highly specific amplification of the desired sequence. PCR also can be used to detect the existence of the defined sequence in a DNA sample..
Industry:Biology
Adding pertinent information such as gene coded for, amino acid sequence, or other commentary to the database entry of raw sequence of DNA bases.
See also: bioinformatics.
Industry:Biology
Difference in DNA sequence among individuals that may underlie differences in health. Genetic variations occurring in more than 1% of a population would be considered useful polymorphisms for genetic linkage analysis.
See also: mutation.
Industry:Biology
Each generation of offspring has increased severity of a genetic disorder; e.g., a grandchild may have earlier onset and more severe symptoms than the parent, who had earlier onset than the grandparent.
See also: additive genetic effects, complex trait.
Industry:Biology
A member of a chromosome pair in diploid organisms or a gene that has the same origin and functions in two or more species..
Industry:Biology
A technique used to identify genes, usually those that are associated with diseases, based on their location on a chromosome..
Industry:Biology
Similarity in DNA or protein sequences between individuals of the same species or among different species..
Industry:Biology
Putting sequenced fragments of DNA into their correct chromosomal positions..
Industry:Biology
